Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Johan Nordholm, Andreas Constantinou, Nina Schiller
Date created: 2010-10-24 11:00:00
Date modified: 2015-05-08 01:12:17
LMWP cell-penetrating peptide
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K380002_sequence (Version 1) |
Description
Low molecular weight protamine (LMWP) is a cell-penetrating peptide that may be used in N- and C-terminal fusions with full-length proteins to create transduction proteins with the ability to permeate the lipid bilayer of various cell types, making it a potential gene or protein delivery vector.Enzymatically prepared LMWP chemically conjugated to ovalbumin (OVA) and bovine serum albumin (BSA) have previously been shown to penetrate the lipid bilayer of human keratinocytes, as well as to successfully permeate mouse skin epidermis (Huang et al., 2010). Furthermore, LMWP/pDNA complexes can efficiently penetrate into human embryonic kidney cells (Park et al., 2003). As LMWP has been shown to be neither toxic nor immunogenic (Chang et al. a, 2001; Chang et al. b, 2001; Lee et al., 2001), it may be used as a potential vaccine, drug or gene delivery vector.
This gene also exists as an N-part, [[Part:BBa_K380003]].