Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Amna Sohail
Date created: 2013-06-09 11:00:00
Date modified: 2015-05-08 01:13:49
Fibroblast Growth Factor-1 Receptor Coding Sequence
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K976000_sequence (Version 1) |
Description
The Fibroblast Growth Factor-1 Receptor (FGFR-1) is a receptor that is commonly found in melanocytes and is involved with melanocyte differentiation, migration, and division. Malignant melanoma is characterized by abnormally high ligand expression of Fibroblast Growth Factor-2 (FGF2), otherwise known as the Basic Fibroblast Growth Factor (BFGF). The FGFR-1 receptor as a high affinity towards binding to the FGF2 ligand present upon the surface of potentially malignant melanocytes, and therefore may be utilized to detect presence of malignant melanoma tumor.Notes
The start codon sequence has been added to the FGFR-1 coding sequence.Source
The part has been derived from a genomic sequence provisioned by the Ensembl Database.| Sequence Annotation | Location | Component / Role(s) |
| Topological Extracellular Domain Helical Transmembrane Domain Cytoplasmic Domain Ig-like C2-type 1 Domain Ig-like C2-type 2 Domain Ig-like C2-type 3 Domain Protein Kinase Domain | 66,1128 1131,1191 1194,2466 75,357 474,738 765,1071 1434,2301 | feature/misc sequence_feature feature/misc sequence_feature sequence_feature feature/misc feature/misc sequence_feature sequence_feature feature/misc sequence_feature feature/misc sequence_feature feature/misc |