Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Sanjana Gurrala, Xiaoyang Feng, Stephen Cain, Orijit Kar, Sahil Sharma
Date created: 2012-04-02 11:00:00
Date modified: 2015-08-31 04:08:29
CH1 domain of human antibody + cleavage site + phoratoxin
| Types | DnaRegion |
| Roles | Composite engineered_region |
| Sequences | BBa_J120028_sequence (Version 1) |
Description
Device is composed of three subunits primarily constant region of ADAM17 antibody (M01), specific cleavage site that is recognized by the proteolytic function of ADAM17 and phoratoxin. These three subunits are arranged in corresponding order. A promoter with a variable region is required that will work in junction with the device. This variable region whose sequence is not known will recognize the ADAM17 present on the cell membrane of the cell and bind to it. The proteolytic function of ADAM17 will recognize the cleavage site and cleave it. This cleavage will result in releasing of phoratoxin which will enter the cell and eventually kill it.Notes
Will be doneSource
Will be done :P| Access | Instance | Definition |
| public public public public | BBa_J120020 BBa_J120023 BBa_J120022 BBa_B0011 | BBa_J120020 BBa_J120023 BBa_J120022 BBa_B0011 |
| Sequence Annotation | Location | Component / Role(s) |
| BBa_J120020 BBa_J120023 BBa_J120022 BBa_B0011 | 1,297 298,327 328,468 469,514 | BBa_J120020 BBa_J120023 BBa_J120022 BBa_B0011 |