Types | DnaRegion
|
Roles | Composite
engineered_region
|
Sequences | BBa_K909015_sequence (Version 1)
|
Description
PABA is derived from the aromatic branch point precursor chorismate in two steps. Aminodeoxychorismate (ADC) synthase converts chorismate and glutamine to ADC and glutamate. The conversion of chorismate and glutamine to ADC and glutamate determines the rate and therefore overexpression of ADC synthase leads to overproduction of pABA. ADC synthase is composed of two subunits, PabA and PabB. Finally ADC lyase removes pyruvate from ADC, aromatizes the ring, and generates PABA.
Notes
pabB and pabA constitute an operon that can be controled by any promoter.
Source
S04039, K137055